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MIDV-682 was isolated in 2005 from a 3-year-old girl in the Democratic Republic of Congo. The isolate was obtained from a skin lesion, and subsequent genetic analysis revealed that it was a distinct strain of the Monkeypox virus.

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The disease progression of MIDV-682 infection is typically mild to moderate, with most patients recovering within 2-4 weeks. However, severe cases can occur, particularly in immunocompromised individuals, and may lead to complications such as pneumonia, encephalitis, and sepsis.