On the Steam version (DX11), you can force splitscreen with a simple -launcher command line tweak. Plug in two controllers, sign in a guest profile. Works for co-op without mods.
The most critical tweak for any modern RE5 player is the plugin. This tool is the foundation for a stable game. re5 tweaks
Launch the game; a configuration menu usually appears (or can be toggled via a hotkey like ) to let you customize your settings. or adjusting the On the Steam version (DX11), you can force